This was recommended by several people. It's early yet but it seems very promising.
Trigun is a science fiction Western, set on a desert planet with bounty hunters, sheriffs, and so forth. Vash the Stampede has a $$60,000,000,000.00 [*] bounty on his head and leaves a trail of destruction in his wake (nicknamed "the Humanoid Typhoon," and I have to think "Human Typhoon" sounds better); however, he's so goofy that people tend not to believe it's actually him, and through four episodes, he's not killed anyone, and indeed gone out of his way to avoid it.
[*] Certain units are given different names, like "double dollars" for currency and "iles" for distance.
Among those seeking Vash are two women who work for an insurance company, the shorter no-nonsense Meryl and the large, soft-voiced, sweet Milly. I like them both so far. Also, there's a cat that appears in each episode (so far), which amuses me: see icon.
I was warned that these first episodes were rather slapsticky, and I suppose in an absolute sense they are, but really, Martian Successor Nadesico has raised my threshold for "slapstick" considerably.
Further comments are spoilers, behind the cut. Spoil me and die.
Though I like Meryl and Milly, and appreciate that they finally got to kick ass in episode 4 (I really liked Meryl shooting out the center of the corrupt sheriff's badge as Vash tossed it up), I don't understand their mission: they say they're trying to find and babysit Vash because the trail of destruction is costing their company so much money, but wouldn't turning him in for the bounty work just as well? I think of bounties as "dead or alive," but maybe it's just "dead"? Or something else unsavory is going on with it.
I liked the importance of water in the second episode. I thought the third episode, with the drunk gunsmith, was a little pat, but I guess they felt the need for something actively positive.
I'm not even going to try and guess what's going on with Vash yet; far too early.
(Patriots scored, but they're about to punt on 4th and 10 with five minutes left. Grr.)